Research
Basic Research:
Currently pursuing PhD under the guidance of Dr. Eric Small, PhD studying the nuclear envelope biology and the epigenetic mechanisms of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) in the Aab Cardiovascular Research Institute (CVRI) at the University of Rochester School of Medicine & Dentistry.
Currently leading research projects investigating the role of the Advanced Glycation End Products (AGEs) and the receptor for Advanced Glycation End Products (RAGE) in E-cigarette-mediated cardiovascular impairment under the guidance of Dr. Leila Mohammadi, MD, PhD and Dr. Matthew L. Springer, PhD in the Division of Cardiology at the University of California, San Francisco (UCSF).
Clinical Research:
Currently involved in clinical cardiac electrophysiology research investigating the role of metabolic syndrome on the ICD and CRT-D outcome under the guidance of Dr. Valentina Kutyifa, MD, PhD in the Clinical Cardiovascular Research Center (CCRC) at the University of Rochester Medical Center.
Currently involved in clinical pediatrics research investigating the role of maternal marijuana exposure on newborn asthma and ADHD under the guidance of Dr. Karen Wilson, MD, MPH in the Department of Pediatrics at the University of Rochester Medical Center.
Currently involved in clinical Adult Congenital Heart Disease (ACHD) research investigating the outcomes of post-Fontan procedure in adult ACHD patients under the guidance of Dr. Pradeepkumar Charla in the Department of Pediatric Cardiology at the University of Rochester Medical Center.
Publications
Selected Publications:
1. Han DD, Rao P, Qiu H, Navabzadeh M, Wang X, Goyal N, Mohammadi L, Huang A, Perez BG, Schick SF, Springer ML. Impairment of endothelial function by cigarette smoke and e-cigarette aerosol requires RAGE. Arterioscler. Thromb. Vasc. Biol. 43:2369-2371.
2. Mohammadi L, Han DD, Xu F, Huang A, Derakhshandeh R, Rao P, Whitlatch A, Keith RJ, Hamburg NM, Ganz P, Hellman J, Schick SF, Springer ML (2022). Chronic e-cigarette use impairs endothelial function on the physiological and cellular levels. Arterioscler. Thromb. Vascular. Biol. 42:1333-1350.
3. Rao P, Han DD, Tan K, Mohammadi L, Derakhshandeh R, Navabzadeh Esmaeili M, Springer ML (2022). Comparable Impairment of Vascular Endothelial Function by a Wide Range of Electronic Nicotine Delivery Devices. Nicotine Tob. Res. 24:1055-1062.
Peer-reviewed Publications:
1. Grable JC, Shan K, Wang M, Han DD, Sportiello K, Chang M, Sysol JR, Bugbee D, Peltzer K (2024). Training Medical Student Counselors for the Rochester Model, a Hospital Tobacco Treatment Program. J. Multidiscip. Healthc. 17:601-607.
2. Liu J*, Nabavizadeh P*, Rao P*, Derakhshandeh R, Han DD, Guo R, Murphy MB, Cheng J, Schick SF, Springer ML (2023). Impairment of Endothelial Function by Aerosol from Marijuana Leaf Vaporizers. J. Am. Heart Assoc. 12:e032969.
3. Han DD, Rao P, Qiu H, Navabzadeh M, Wang X, Goyal N, Mohammadi L, Huang A, Perez BG, Schick SF, Springer ML (2023). Impairment of endothelial function by cigarette smoke and e-cigarette aerosol requires RAGE. Arterioscler. Thromb. Vasc. Biol. 43:2369-2371.
4. Wang X*, Gaur M*, Mounzih K, Rodriguez HJ, Qiu H, Chen M, Yan L, Cooper BA, Narayan S, Derakhshandeh R, Rao P, Han DD, Nabavizadeh P, Springer ML, John CM (2023). Inhibition of galectin-3 post-infarction impedes progressive fibrosis by regulating inflammatory profibrotic cascades. Cardiovasc. Res. 119:2536-2549.
5. Mohammadi L, Han DD, Xu F, Huang A, Derakhshandeh R, Rao P, Whitlatch A, Keith RJ, Hamburg NM, Ganz P, Hellman J, Schick SF, Springer ML (2022). Chronic e-cigarette use impairs endothelial function on the physiological and cellular levels. Arterioscler. Thromb. Vascular. Biol. 42:1333-1350.
6. Qiu H, Zhang H, Han DD, Derakhshandeh R, Wang X, Goyal N, Navabzadeh M, Rao P, Wilson EE, Mohammadi L, Olgin JE, Springer ML (2022). Increased vulnerability to atrial and ventricular arrhythmias caused by different forms of inhaled tobacco or marijuana products. Heart Rhythm. 20:76-86.
7. Nabavizadeh P*, Liu J*, Rao P, Ibrahim S, Han DD, Derakhshandeh R, Mohammadi L, Qiu H, Wang X, Glantz SA, Schick SF, Springer ML (2022). Impairment of endothelial function by cigarette smoke is not caused by a specific smoke constituent, but by vagal input from the airway. Arterioscler. Thromb. Vasc. Biol. 42:1324-1332.
8. Rao P, Han DD, Tan K, Mohammadi L, Derakhshandeh R, Navabzadeh Esmaeili M, Springer ML (2022). Comparable Impairment of Vascular Endothelial Function by a Wide Range of Electronic Nicotine Delivery Devices. Nicotine Tob. Res. 24:1055-1062.
9. Wang X, Chacon LI, Derakhshandeh R, Rodriguez HJ, Han DD, Kostyushev DS, Henry TD, Traverse JH, Moye L, Simari RD, Taylor DA, Springer ML (2020). Impaired therapeutic efficacy of bone marrow cells from post-myocardial infarction patients in the TIME and LateTIME clinical trials. PLoS ONE 15(8): e0237401.
Abstracts:
1. Han DD, Miedlich S, Zaraba W, Goldenberg I, McNitt S, Kutyifa V. Outcomes in Non-obese Heart Failure Patients with Metabolic Syndrome or Diabetes. Heart Rhythm. 2024. 21(5):S671-S672.
2. Mohammadi L, Navabzadeh M, Han DD, Reagan E, Naughton J, Zhou L, Almeida R, Park K, Uyemura K, Goyal N, Rao P, Hellman J, Cheng J, Marcus GM, Springer ML. Impairment of endothelial function by chronic cannabis use: An interim analysis of the CANDIDE study. Circulation. 2023. 148 (Suppl_1):A14589-A14589.
3. Han DD, Qiu H, Wang X, Navabzadeh M, Goyal N, Mohammadi L, Springer ML. Vascular Impairment From Acute Exposure To E-cigarette Aerosol Is Rescued By Inhibition Of The Receptor For Advanced Glycation End Products (RAGE). Arterioscler Thromb Vasc Biol. 2022. 42 (Suppl_1):A136-A136.
4. Han DDW, Xu F, Derakhshandeh R, Huang A, Whitlatch A, Keith RJ, Hamburg NM, Ganz P, Hellman J, Schick SF, Springer ML, Mohammadi L. (2021) Inhibition of Receptor for Advanced Glycation End Products (RAGE) reduces e-cigarette-induced increase in endothelial permeability. Circulation. 144 (Suppl_1):A9929-A9929
5. Mohammadi L, Han DDW, Fang X, Xu F, Derakhshandeh R, Hellman J, Gotts J, Springer ML (2021) Increased pulmonary microvascular endothelial permeability by e-cigarette aerosol: the pathway from lung to peripheral blood vessels. Circulation. 144 (Suppl_1):A11496-A11496.
6. Wang X, Qiu H, Han DDW, Tan K, Derakhshandeh R, Springer ML. (2021) Adverse effects of smoking/vaping of several types of tobacco products and marijuana on cardiac function and platelet aggregation. Circulation. 2021. 144 (Suppl_1):A9869-A9869.
7. Qiu H, Zhang H, Derakhshandeh R, Wang X, Wilson EE, Rao P, Han DDW, Mohammadi L, Olgin JE, Springer ML (2021) Increased Susceptibility to Arrhythmias, Hypertension, and Hypertrophy in a Rat Model of Exposure to Electronic, Heat-Not-Burn, or Conventional Cigarettes, or Marijuana. Circulation. 144 (Suppl_1):A9922-A9922.
8. Rao P, Tan K, Han DDW, Derakhshandeh R, Springer ML. (2021) Comparable Impairment of Vascular Endothelial Function by a Wide Range of Electronic Nicotine Delivery Devices. Circ. Res. 129 (Suppl_1):A355-A355.
9. Rao P, Nabavizadeh P, Han D, Schick SF, Springer ML (2020) Aldehydes in cigarette smoke impair vascular endothelial function. Circ. Res. 127 (Suppl_1):A236-A236.
10. Mohammadi L, Han D, Derakhshandeh R, Huang A, Whitlatch A, Xu F, Keith RJ, Hamburg N, Ganz P, Hellman J, Schick SF, Springer ML (2020) Functional impairment of endothelial cells in vitro after exposure to serum from e-cigarette users. Arterioscler. Thromb. Vasc. Biol. 40 (Suppl_1):A522-A522.
11. Wang X, Derakhshandeh R, Rodriguez HJ, Han DD, Kostyushev DS, et al. (2019). Impaired therapeutic efficacy of bone marrow cells from post-myocardial infarction patients in the TIME and LateTIME clinical trials (ASGCT 22nd Annual Meeting, Abstract #712). Mol. Ther. 27 (Suppl_1):337.
12. Mohammadi L, Derakhshandeh R, Han DD, Whitlatch A, Huang A, Schick SF, Springer ML (2018) Relative Endothelial Toxicity of Tobacco Smoke and E-Cigarette Aerosol: A Functional and Mechanistic Assessment. Circulation. 138 (Suppl_1):A16844-A16844.
